For safety reason, oxygen should be treated like any other prescription drug with the orders for therapy included in a treatment (medication) chart before administration. As a result of these documented harmful effects of out of controlled oxygen administration, the use of titrated oxygen therapy in the vulnerable patient group has been recommended for many years by safety agency and several international respiratory societies. Uncontrolled oxygen administration, mainly when delivered at high concentrations, can result in a worsening of hypercapnia which is primarily caused by hypoxic vasoconstriction and not due to reduced hypoxic drive as previously believed. The inappropriate administration also leads to increased hospital lengths of stay, higher rates of admission to high dependency units, and an increased risk of death. Excessive administration of oxygen can be harmful, especially in chronic obstructive pulmonary disease (COPD) patients with hypercapnic respiratory failure and those with other pulmonary conditions associated with hypercapnic respiratory failure. However, recent clinical data from systematic reviews and randomized clinical trial on the use of acute oxygen therapy in patients with stroke and acute myocardial infarction have disapproved this notion. It was erroneously and previously believed that too much oxygen would not hurt. The gas is like any other medical drug, and when used appropriately it can reduce mortality, and when administered wrongly it may be harmful to the recipient and resulting in adverse consequences. Low oxygen level in the blood can result in cellular dysfunction, organ failure, and death. Oxygen is a commonly used medication in the clinical setting.

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